Description

Methyl 1-(4-Fluorophenyl)Cyclobutane-1-Carboxylate is a high-purity fluorinated cyclobutane derivative, serving as a critical advanced pharmaceutical intermediate (API) and versatile building block in organic synthesis. Its value lies in the unique structural combination of the cyclobutane ring and the fluorinated aromatic moiety, which is instrumental in modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients requiring enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorophenyl group can enhance activity and environmental stability.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and liquid crystals with tailored optical and electronic properties.
• Organic Synthesis Reagent: A versatile synthon for constructing complex molecular architectures via reactions like cross-coupling, ring-opening, and functional group transformations.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a labeled compound in metabolic pathway research.

Basic Information

Product Name	Methyl 1-(4-Fluorophenyl)Cyclobutane-1-Carboxylate
CAS No.	1090553-79-9
Molecular Formula	C12H13FO2
Molecular Weight	208.23 g/mol
Synonyms	Methyl 1-(4-fluorophenyl)cyclobutanecarboxylate; 1-(4-Fluorophenyl)cyclobutanecarboxylic acid methyl ester; Methyl 1-(p-fluorophenyl)cyclobutanecarboxylate; 1-(4-Fluorophenyl)cyclobutanecarboxylic Acid Methyl Ester; Methyl 4-Fluorophenylcyclobutanecarboxylate; MFCC; 1090553-79-9
EINECS	Contact for details

Quality Control

Our production of Methyl 1-(4-Fluorophenyl)Cyclobutane-1-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and current industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider using an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.