Description

Cyclobutanol, 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- is a high-value, protected alcohol intermediate featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound matters for its role as a key synthon in advanced organic synthesis, where the silyl protecting group provides exceptional stability under a wide range of reaction conditions, enabling complex multi-step transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for complex, small-molecule drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the cyclobutane scaffold offers unique biological activity.
• Material Science Research: Acts as a monomer or precursor for developing advanced polymers and functional materials with specific thermal or mechanical properties.
• Asymmetric Synthesis: Employed in stereoselective reactions to create chiral centers, essential for producing enantiomerically pure compounds.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed and other metal-mediated coupling reactions to form carbon-carbon bonds.
• Protecting Group Strategy: The TBDMS group allows for selective manipulation of other functional groups within a molecule, a fundamental technique in complex molecule assembly.

Basic Information

Product Name	Cyclobutanol, 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-
CAS No.	1089709-08-9
Molecular Formula	C10H22O2Si
Molecular Weight	202.37 g/mol
Synonyms	3-((tert-Butyldimethylsilyl)oxy)cyclobutanol; 3-(tert-Butyldimethylsiloxy)cyclobutanol; 3-TBDMS-oxycyclobutanol; 3-[(tert-Butyldimethylsilyl)oxy]cyclobutan-1-ol; Cyclobutan-3-ol, 1-[(1,1-dimethylethyl)dimethylsilyl] ether; 1-[(tert-Butyldimethylsilyl)oxy]cyclobutan-3-ol; TBDMS ether of 3-hydroxycyclobutanol
EINECS	Contact for details

Quality Control

Our Cyclobutanol, 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali. Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.