Description

Ethyl 6-Iodobenzofuran-2-Carboxylate is a high-purity, functionalized benzofuran derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic placement of the iodine atom, which enables versatile cross-coupling reactions for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators requiring halogenated heterocyclic cores.
• Material Science Precursor: Serves as a monomer or functional unit in the synthesis of organic electronic materials, such as OLEDs and conductive polymers.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for Suzuki, Stille, and Sonogashira couplings to introduce the benzofuran scaffold into larger systems.
• Chemical Biology Probes: Utilized in the creation of tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Scale-Up: Supplied for contract research organizations (CROs) and CDMOs engaged in custom synthesis from milligram to kilogram scale.

Basic Information

Item	Details
Product Name	Ethyl 6-Iodobenzofuran-2-Carboxylate
CAS No.	1089681-88-8
Molecular Formula	C11H9IO3
Molecular Weight	316.09 g/mol
Synonyms	6-Iodobenzofuran-2-carboxylic acid ethyl ester; Ethyl 6-iodo-1-benzofuran-2-carboxylate; 2-Benzofurancarboxylic acid, 6-iodo-, ethyl ester; Ethyl 6-iodobenzofuran-2-carboxylate; 1089681-88-8; 6-Iodo-benzofuran-2-carboxylic acid ethyl ester; Ethyl 6-iodo-2-benzofurancarboxylate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 6-Iodobenzofuran-2-Carboxylate is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, with purity typically exceeding 97% (HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.