Description

5-Fluoro-2-[[(3R,6R)-6-Methyl-3-Piperidinyl]Methoxy]Pyridine is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and functional groups, which make it a critical precursor in the synthesis of complex, biologically active molecules. This compound is primarily needed by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly within the central nervous system (CNS) and oncology spaces.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Asymmetric Synthesis: Serves as a valuable chiral scaffold for constructing complex molecules with defined stereocenters.
• Preclinical & Clinical Trial Material: Manufactured under GMP-like conditions for the production of compounds used in non-clinical and clinical studies.
• Ligand & Catalyst Development: Potential use in the development of chiral ligands or organocatalysts for asymmetric transformations.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	5-Fluoro-2-[[(3R,6R)-6-Methyl-3-Piperidinyl]Methoxy]Pyridine
CAS No.	1088993-93-4
Molecular Formula	C12H17FN2O
Molecular Weight	224.28 g/mol
Synonyms	(3R,6R)-6-Methyl-3-((5-fluoropyridin-2-yl)oxy)methyl)piperidine; 2-[[(3R,6R)-6-Methyl-3-piperidinyl]methoxy]-5-fluoropyridine; 5-Fluoro-2-[[(3R,6R)-6-methylpiperidin-3-yl]methoxy]pyridine; (3R,6R)-6-Methyl-3-((5-fluoropyridin-2-yl)oxy)methyl)piperidine; 1088993-93-4; (R,R)-6-Methyl-3-((5-fluoropyridin-2-yl)oxy)methyl)piperidine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-[[(3R,6R)-6-Methyl-3-Piperidinyl]Methoxy]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure stereochemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our quality commitment supports compliance with the stringent requirements of pharmaceutical development and cGMP guidelines for investigational materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.