Description

6-Azaspiro[2.5]Octane-1-Carboxylic Acid Ethyl Ester is a high-value, nitrogen-containing spirocyclic building block of significant interest in advanced organic synthesis. Its unique bridged bicyclic structure makes it a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily sought after by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within the central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in scaffold hopping and lead optimization to explore new chemical space and improve drug-like properties.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for potential APIs.
• Agrochemical Synthesis: Potential use in creating novel active ingredients for crop protection products, leveraging its spirocyclic motif.
• Academic & Contract Research: Employed in universities and CROs for methodological studies and the discovery of new bioactive molecules.
• Chemical Biology Probes: Can be incorporated into tool compounds for studying biological pathways and target engagement.

Basic Information

Product Name	6-Azaspiro[2.5]Octane-1-Carboxylic Acid Ethyl Ester
CAS No.	1088498-24-1
Molecular Formula	C10H17NO2
Molecular Weight	183.25 g/mol
Synonyms	Ethyl 6-Azaspiro[2.5]octane-1-carboxylate; 1-(Ethoxycarbonyl)-6-azaspiro[2.5]octane; 6-Azaspiro[2.5]octane-1-carboxylic acid ethyl ester; Azaspirooctane carboxylate ester; 1-Carbethoxy-6-azaspiro[2.5]octane; 6-Aza-spiro[2.5]octane-1-carboxylic acid ethyl ester; Ethyl 1-azaspiro[2.5]octane-6-carboxylate (isomer); 1088498-24-1
EINECS	Contact for details

Quality Control

Our 6-Azaspiro[2.5]Octane-1-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.