Description

5-Bromopyridin-3-Yl tert-Butyl Carbonate is a high-purity, protected pyridine derivative used as a versatile synthetic intermediate in advanced organic synthesis. Its value lies in the strategic combination of a bromo substituent and a tert-butyl carbonate protecting group, enabling selective functionalization and controlled reactivity. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, particularly for constructing complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides requiring specific pyridine-based structures.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and photoactive materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination.
• Protecting Group Chemistry: The tert-butyl carbonate (Boc) group can be selectively removed under mild acidic conditions, allowing for orthogonal synthesis strategies.
• Chemical Library Development: A valuable reagent for medicinal chemistry and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	5-Bromopyridin-3-Yl tert-Butyl Carbonate
CAS No.	1087659-21-9
Molecular Formula	C10H12BrNO3
Molecular Weight	274.11 g/mol
Synonyms	tert-Butyl (5-bromopyridin-3-yl) carbonate; 3-Bromo-5-[(tert-butoxy)carbonyloxy]pyridine; 5-Bromo-3-pyridyl tert-butyl carbonate; 5-Bromo-3-pyridinol, 1,1-dimethylethyl carbonate; Boc-Protected 5-Bromo-3-hydroxypyridine; 1087659-21-9; (5-Bromopyridin-3-yloxy)-tert-butylcarboxylate
EINECS	Contact for details

Quality Control

Our 5-Bromopyridin-3-Yl tert-Butyl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your R&D and scale-up activities with reliable and traceable data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.