Description

4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel, biologically active molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitor drug candidates, particularly for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Organic Synthesis Building Block: The triisopropylsilyl (TIPS) protecting group and carboxylic acid functionality allow for selective derivatization and further molecular elaboration.
• Bioconjugation & Probe Development: The carboxylic acid group enables coupling to amines, facilitating the creation of fluorescent probes or targeted conjugates for biological studies.
• Process Chemistry & Scale-Up: Serves as a defined intermediate in the pilot-scale and commercial-scale synthesis of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid
CAS No.	1086423-46-2
Molecular Formula	C17H25ClN2O2Si
Molecular Weight	352.93 g/mol
Synonyms	4-Chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 4-chloro-1-[(1,1-dimethylethyl)dimethylsilyl]-; 4-Chloro-1-TIPS-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; TIPS-protected 4-chloropyrrolopyridine-5-carboxylate; 1086423-46-2; 4-Chloro-1-(triisopropylsilyl)-7-azaindole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is stable under inert atmosphere. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.