Description

n-Hydroxy-11-Azaartemisinin CAS NO 1086409-82-6 is a chemically modified derivative of the potent antimalarial natural product artemisinin, featuring an aza-substitution and a hydroxyl group. This structural modification is of significant interest for the development of novel pharmaceutical agents with potential enhanced activity, altered pharmacokinetics, or reduced susceptibility to resistance. It serves as a critical advanced intermediate and research chemical for medicinal chemists and pharmaceutical developers targeting infectious diseases and exploring new therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation antimalarial compounds and other chemotherapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the efficacy and safety profile of artemisinin-based drug candidates.
• Antiparasitic Drug Development: Investigated for potential activity against a range of parasitic infections beyond malaria.
• Biochemical Tool Compound: Employed in mechanistic studies to understand the mode of action of artemisinin derivatives at the molecular level.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for exploratory pharmacology and drug discovery projects.
• API (Active Pharmaceutical Ingredient) Synthesis: A potential precursor in the multi-step synthesis of complex active pharmaceutical ingredients for clinical evaluation.

Basic Information

Product Name	n-Hydroxy-11-Azaartemisinin
CAS No.	1086409-82-6
Molecular Formula	C15H23NO6
Molecular Weight	313.35 g/mol
Synonyms	11-Azaartemisinin, N-hydroxy; 11-Aza-dihydroartemisinin, N-hydroxy derivative; Artemisinin, 11-aza-, N-hydroxy; 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, 11-aza-, N-hydroxy; N-Hydroxy-11-aza-dihydroartemisinin
EINECS	Contact for details

Quality Control

Our n-Hydroxy-11-Azaartemisinin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.