Description

1,8-Diazaspiro[5.5]undecan-8-carboxylic acid tert-butyl ester is a high-value, protected spirocyclic amine building block essential for advanced organic synthesis. This compound is critical for medicinal chemistry research and development, serving as a versatile scaffold for constructing complex molecules with potential biological activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Scaffold: Used as a rigid, spirocyclic core structure for constructing focused libraries in hit-to-lead and lead optimization programs.
• Protease Inhibitor Development: Serves as a building block for molecules designed to inhibit specific enzymes like proteases, which are relevant in various disease pathways.
• Chemical Biology Probes: Employed in the creation of molecular tools for studying biological processes and target validation.
• Agrochemical Research: Utilized as an intermediate in the development of novel, high-performance crop protection agents.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge synthetic methodology and heterocyclic chemistry research.

Basic Information

Product Name	1,8-Diazaspiro[5.5]undecan-8-carboxylic acid tert-butyl ester
CAS No.	1086394-59-3
Molecular Formula	C14H26N2O2
Molecular Weight	254.37 g/mol
Synonyms	tert-Butyl 1,8-diazaspiro[5.5]undecane-8-carboxylate; 8-(tert-Butoxycarbonyl)-1,8-diazaspiro[5.5]undecane; 1,8-Diazaspiro[5.5]undecane-8-carboxylic acid, 1,1-dimethylethyl ester; Boc-1,8-diazaspiro[5.5]undecane; 8-Boc-1,8-diazaspiro[5.5]undecane; Spirocyclic amine Boc-protected; 1,8-Diazaspiro[5.5]undecan-8-carboxylate tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1,8-Diazaspiro[5.5]undecan-8-carboxylic acid tert-butyl ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the exacting standards of pharmaceutical development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.