Description

2-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Yloxy)-Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is essential for research institutions, CROs, CDMOs, and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used in the research and production of protease inhibitors for antiviral and anticancer therapies.
• Kinase Inhibitor Development: Serves as a core scaffold in the design and synthesis of novel kinase inhibitors for targeted cancer treatments.
• Peptidomimetic Chemistry: Employed in the construction of peptidomimetics, which are molecules that mimic peptides for enhanced drug stability and bioavailability.
• Medicinal Chemistry Research: A valuable tool for medicinal chemists in structure-activity relationship (SAR) studies and lead optimization.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of clinical trial materials and commercial APIs.

Basic Information

Product Name	2-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Yloxy)-Nicotinic Acid
CAS No.	1086392-88-2
Molecular Formula	C15H20N2O5
Molecular Weight	308.33 g/mol
Synonyms	2-[(1-tert-Butoxycarbonylpyrrolidin-3-yl)oxy]nicotinic Acid; 2-((1-(tert-Butoxycarbonyl)-3-pyrrolidinyl)oxy)-3-pyridinecarboxylic Acid; Nicotinic acid, 2-[(1-[(1,1-dimethylethoxy)carbonyl]-3-pyrrolidinyl)oxy]-; 2-(1-Boc-3-pyrrolidinyloxy)nicotinic Acid; 2-(N-Boc-3-pyrrolidinyloxy)nicotinic Acid; Boc-Pyrrolidin-3-yloxy-Nicotinic Acid
EINECS	Contact for details

Quality Control

Our 2-(1-tert-Butoxycarbonyl-Pyrrolidin-3-Yloxy)-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support development under ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.