Description

4-Iodo-3-Methyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its core value lies in providing a versatile, functionalized scaffold for constructing complex nitrogen-containing molecules with precise stereochemistry. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the research and development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce iodine and methyl substituents for molecular diversification and property modulation.
• Process Chemistry & Scale-up: Serves as a protected intermediate in the multi-step synthesis of complex molecules, where the tert-butyloxycarbonyl (Boc) group offers orthogonal protection for the piperidine nitrogen.
• Agrochemical Development: Employed in the research of novel pesticides and herbicides that utilize functionalized piperidine cores for enhanced biological activity.
• Ligand & Catalyst Synthesis: A precursor for creating specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: The iodine atom provides a handle for further functionalization via cross-coupling reactions, useful for creating labeled compounds for biological studies.

Basic Information

Product Name	4-Iodo-3-Methyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1086392-74-6
Molecular Formula	C11H20INO2
Molecular Weight	325.19 g/mol
Synonyms	1-Boc-4-iodo-3-methylpiperidine; tert-Butyl 4-iodo-3-methylpiperidine-1-carboxylate; 3-Methyl-4-iodopiperidine-1-carboxylic acid tert-butyl ester; 4-Iodo-3-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-N-Boc-4-iodo-3-methylpiperidine; BOC-4-Iodo-3-methylpiperidine; 1086392-74-6
EINECS	Contact for details

Quality Control

Our 4-Iodo-3-Methyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our production adheres to cGMP standards where applicable, ensuring reliable batch-to-batch consistency for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to minimize degradation. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.