Description

4-Bromo-2-tert-Butoxypyridine is a high-purity brominated pyridine derivative, a crucial building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides a reactive halogen site and a sterically hindered alkoxy group for selective functionalization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its pyridine core for biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological systems and protein interactions.
• Custom Synthesis and Scale-up: Supports contract research and manufacturing organizations (CROs/CMOs) in process development from milligram to kilogram scale.

Basic Information

Product Name	4-Bromo-2-tert-Butoxypyridine
CAS No.	1086381-36-3
Molecular Formula	C9H12BrNO
Molecular Weight	230.10 g/mol
Synonyms	2-(tert-Butoxy)-4-bromopyridine; 4-Bromo-2-(tert-butoxy)pyridine; 4-Bromo-2-(1,1-dimethylethoxy)pyridine; Pyridine, 4-bromo-2-(1,1-dimethylethoxy)-; 4-Bromo-2-O-tert-butylpyridine; 2-tert-Butoxy-4-bromopyridine; 4-Bromo-2-t-butoxypyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-tert-Butoxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and regulatory compliance (REACH, TSCA) ensures a reliable supply for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.