Description

2-Bromo-6-Cyclopropylpyridine is a high-purity, versatile brominated heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both a bromine substituent and a cyclopropyl ring on the pyridine core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the cyclopropyl moiety for bioactivity.
• Cross-Coupling Reactions: Serves as a crucial electrophilic partner in Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Ligand and Catalyst Development: Employed in the preparation of specialized nitrogen-containing ligands for asymmetric catalysis and material science applications.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a building block for constructing linkers and warheads in the development of targeted protein degraders.
• Material Science Research: Acts as a monomer or functionalization agent in the synthesis of organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Bromo-6-Cyclopropylpyridine
CAS No.	1086381-26-1
Molecular Formula	C8H8BrN
Molecular Weight	198.06 g/mol
Synonyms	6-Cyclopropyl-2-bromopyridine; 2-Bromo-6-cyclopropyl-pyridine; Pyridine, 2-bromo-6-cyclopropyl-; 2-Bromanyl-6-cyclopropylpyridine; BRD-K94212519; AKOS026714011; ZINC000257666679; A1-00304
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Cyclopropylpyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.