Description

4-{[6-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Aniline is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylpyridine and aniline ether structure. This compound matters as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. Pharmaceutical R&D and agrochemical manufacturers need this specialized intermediate to develop next-generation drugs and crop protection agents targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drugs, especially kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, leveraging the trifluoromethyl group for improved efficacy.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic systems in asymmetric synthesis.
• Life Science Reagents: Utilized in biochemical research for probe and tracer molecule synthesis due to its fluorescent potential and structural motif.

Basic Information

Product Name	4-{[6-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Aniline
CAS No.	1086378-51-9
Molecular Formula	C12H9F3N2O
Molecular Weight	254.21 g/mol
Synonyms	4-((6-(Trifluoromethyl)pyridin-2-yl)oxy)aniline; 2-((4-Aminophenoxy)-6-(trifluoromethyl)pyridine; 4-(6-Trifluoromethylpyridin-2-yloxy)aniline; 4-Aminophenyl 6-(trifluoromethyl)pyridin-2-yl ether; Benzenamine, 4-[[6-(trifluoromethyl)-2-pyridinyl]oxy]-; 1086378-51-9; 4-(6-Trifluoromethyl-2-pyridyloxy)aniline; 4-(6-(Trifluoromethyl)pyridin-2-yloxy)benzenamine
EINECS	Contact for details

Quality Control

Our 4-{[6-(Trifluoromethyl)Pyridin-2-Yl]Oxy}Aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.