Description

3-Iodo-2-Piperidin-1-Ylpyridine CAS NO 1086376-23-9 is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a pyridine core, a piperidine substituent, and a reactive iodine atom, enabling precise molecular construction. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, kinase inhibitors, and other biologically active molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the pyridine-piperidine scaffold can confer specific biological activity.
• Material Science Chemistry: Acts as a building block for creating functionalized ligands, organic semiconductors, or metal-organic frameworks (MOFs) due to its coordinating nitrogen atoms and modifiable iodine site.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form new carbon-carbon bonds.
• Medicinal Chemistry Library Synthesis: Employed in high-throughput and parallel synthesis to generate diverse compound libraries for biological screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Useful for synthesizing tagged or labeled molecules used as probes to study biological processes and protein interactions.

Basic Information

Product Name	3-Iodo-2-Piperidin-1-Ylpyridine
CAS No.	1086376-23-9
Molecular Formula	C10H13IN2
Molecular Weight	288.13 g/mol
Synonyms	3-Iodo-2-(piperidin-1-yl)pyridine; 2-(1-Piperidinyl)-3-iodopyridine; 3-Iodo-2-piperidin-1-yl-pyridine; Pyridine, 3-iodo-2-(1-piperidinyl)-; 1086376-23-9; 3-Iodo-2-(1-piperazinyl)pyridine (common misnomer); 3-I-2-PP
EINECS	Contact for details

Quality Control

Our 3-Iodo-2-Piperidin-1-Ylpyridine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality systems support development and cGMP manufacturing requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.