Description

3-Bromo-5-(Pyrrolidin-1-Ylsulfonyl)Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its bromopyridine core functionalized with a pyrrolidine sulfonamide group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small molecule therapeutics, particularly for central nervous system (CNS) and oncology targets. Its specific structure makes it valuable for creating compounds with enhanced binding affinity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for experimental and commercial drugs.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Kinase Inhibitor Development: Serves as a core scaffold for designing potent and selective kinase inhibitors, relevant in oncology research.
• CNS Drug Discovery: Employed in the construction of molecules targeting neurological disorders due to the favorable properties of the pyridine moiety.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial scale-up projects.

Basic Information

Product Name	3-Bromo-5-(Pyrrolidin-1-Ylsulfonyl)Pyridine
CAS No.	1086064-89-2
Molecular Formula	C9H11BrN2O2S
Molecular Weight	291.17 g/mol
Synonyms	3-Bromo-5-(pyrrolidine-1-sulfonyl)pyridine; 5-Bromo-3-(pyrrolidin-1-ylsulfonyl)pyridine; Pyridine, 3-bromo-5-(1-pyrrolidinylsulfonyl)-; 1086064-89-2; 3-Bromo-5-pyrrolidin-1-ylsulfonylpyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Pyrrolidin-1-Ylsulfonyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.