Description

5-Bromo-1,2-Dihydro-3H-Pyrazolo[3,4-B]Pyridin-3-One is a high-value brominated heterocyclic building block of significant interest in modern pharmaceutical research and development. This compound serves as a critical synthetic intermediate for constructing complex molecular architectures, enabling the discovery of novel bioactive molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for targeted synthesis programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small molecule drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns for constructing fused pyrazolopyridine scaffolds with potential biological activity.
• Agrochemical Development: Serves as a building block for creating novel active ingredients in crop protection research.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.
• Academic Research: Employed in university and institutional labs for methodological studies in heterocyclic chemistry and new reaction development.

Basic Information

Product Name	5-Bromo-1,2-Dihydro-3H-Pyrazolo[3,4-B]Pyridin-3-One
CAS No.	1086064-44-9
Molecular Formula	C6H4BrN3O
Molecular Weight	214.02 g/mol
Synonyms	5-Bromo-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one; 5-Bromo-3H-pyrazolo[3,4-b]pyridin-3-one; 5-Bromo-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 1086064-44-9; 5-Bromo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridin-3-one; 5-Bromopyrazolo[3,4-b]pyridin-3-one; 5-Bromo-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,2-Dihydro-3H-Pyrazolo[3,4-B]Pyridin-3-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced to relevant ICH guidelines and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.