Description

(S)-tert-Butyl 1-(5-Nitropyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex drug candidates, especially in neurological and psychiatric disorder research.
• API Development: Used in the research and process development stages for creating new Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Serves as a precursor in catalytic and stoichiometric asymmetric synthesis due to its defined (S)-configuration.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control.

Basic Information

Item	Detail
Product Name	(S)-tert-Butyl 1-(5-Nitropyridin-2-Yl)Pyrrolidin-3-Ylcarbamate
CAS No.	1085841-14-0
Molecular Formula	C14H20N4O4
Molecular Weight	308.33 g/mol
Synonyms	(S)-tert-Butyl 1-(5-nitropyridin-2-yl)pyrrolidin-3-ylcarbamate; tert-Butyl N-[(3S)-1-(5-nitropyridin-2-yl)pyrrolidin-3-yl]carbamate; (S)-1-(5-Nitro-2-pyridinyl)-3-[(tert-butoxycarbonyl)amino]pyrrolidine; (3S)-1-(5-Nitropyridin-2-yl)pyrrolidin-3-yl carbamic acid tert-butyl ester; (S)-Boc-3-amino-1-(5-nitropyridin-2-yl)pyrrolidine; (S)-3-((tert-Butoxycarbonyl)amino)-1-(5-nitropyridin-2-yl)pyrrolidine; (S)-tert-Butyl (1-(5-nitropyridin-2-yl)pyrrolidin-3-yl)carbamate
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 1-(5-Nitropyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity compliant with pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.