Description

3-Pyridinecarboxylic Acid, 6-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-, Ethyl Ester is a high-purity, chiral organic compound featuring a pyridine core integrated with a dihydrooxazole (oxazoline) moiety. This specific stereochemistry and functional group arrangement make it a valuable chiral building block and intermediate for sophisticated chemical synthesis. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials where precise stereochemical control is critical.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for creating molecules with specific three-dimensional configurations.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Ligand Precursor: Acts as a starting material for the synthesis of chiral oxazoline-based ligands, which are crucial in asymmetric catalysis for producing enantiomerically enriched compounds.
• Academic & Industrial Research: Employed in chemical research for method development, studying reaction mechanisms, and exploring new synthetic pathways in organic chemistry.
• Material Science: Potential use as a monomer or functional additive in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	3-Pyridinecarboxylic Acid, 6-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-, Ethyl Ester
CAS No.	1085431-16-8
Molecular Formula	C17H16N2O3
Molecular Weight	296.32 g/mol
Synonyms	Ethyl 6-[(4R)-4,5-dihydro-4-phenyl-1,3-oxazol-2-yl]pyridine-3-carboxylate; (R)-Ethyl 6-(4-phenyl-4,5-dihydrooxazol-2-yl)nicotinate; (4R)-4,5-Dihydro-4-phenyl-2-[5-(ethoxycarbonyl)-2-pyridinyl]-Oxazole; 1085431-16-8; (R)-2-(5-(Ethoxycarbonyl)pyridin-2-yl)-4-phenyl-4,5-dihydrooxazole; Nicotinic acid, 6-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-, ethyl ester; A chiral oxazoline-pyridine ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity (enantiomeric excess), to ensure it meets the exacting standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.