Description

1-Ethyl-n-[2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Pyridinyl]-1H-Pyrazole-4-Sulfonamide is a high-value, organoboron-containing intermediate of significant importance in modern synthetic chemistry. Its core value lies in its role as a key building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with complex aromatic backbones.
• Material Science: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Synthesis: Enables the formation of carbon-carbon bonds in complex molecule assembly for academic and industrial R&D.
• Ligand & Catalyst Development: Can be utilized to create novel bidentate ligands or functionalized catalysts for transition metal catalysis.
• Library Synthesis: Ideal for generating diverse compound libraries via parallel synthesis for high-throughput screening in drug discovery.

Basic Information

Product Name	1-Ethyl-n-[2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Pyridinyl]-1H-Pyrazole-4-Sulfonamide
CAS No.	1083326-81-1
Molecular Formula	C17H25BN4O5S
Molecular Weight	408.28 g/mol
Synonyms	1-Ethyl-N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]-1H-pyrazole-4-sulfonamide; 1-Ethyl-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-1H-pyrazole-4-sulfonamide; 1083326-81-1; 1H-Pyrazole-4-sulfonamide, 1-ethyl-N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-; B-1083326-81-1; 1-Ethyl-N-(2-methoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-1H-pyrazole-4-sulfonamide; Pyrazole-boronic ester pinacol sulfonamide derivative.
EINECS	Contact for details

Quality Control

Our 1-Ethyl-n-[2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Pyridinyl]-1H-Pyrazole-4-Sulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your GMP and ISO-compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (argon/nitrogen) when opening to prevent decomposition. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.