Description

n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Cyclopropanesulfonamide is a high-purity boronic ester derivative and a key pharmaceutical intermediate used in modern drug discovery. Its primary value lies in enabling Suzuki-Miyaura cross-coupling reactions, a critical step for constructing complex biaryl structures found in active pharmaceutical ingredients (APIs). This compound is essential for research and development laboratories, as well as production facilities, focused on creating novel therapeutics in oncology, neurology, and other disease areas.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those containing pyridine and cyclopropane motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal chemistry for API development.
• Research & Development (R&D): Used in academic and industrial labs for exploring new chemical entities and optimizing synthetic routes for potential therapeutics.
• Process Chemistry & Scale-Up: Serves as a key material for process development and the pilot-scale or commercial-scale manufacturing of target molecules.
• Ligand and Catalyst Development: Can be utilized in the research of novel ligands or organometallic catalysts for advanced synthetic methodologies.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and herbicides.
• Material Science: May find application in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Cyclopropanesulfonamide
CAS No.	1083326-71-9
Molecular Formula	C15H23BN2O5S
Molecular Weight	354.23 g/mol
Synonyms	Cyclopropanesulfonamide, N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-; 3-(Cyclopropylsulfamoyl)-2-methoxypyridine-5-boronic acid pinacol ester; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(cyclopropylsulfonyl)pyridin-3-amine; 1083326-71-9; Boronic acid, B-[3-[(cyclopropylsulfonyl)amino]-2-methoxy-5-pyridinyl]-, pinacol ester; N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)cyclopropanesulfonamide
EINECS	Contact for details

Quality Control

Our n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Cyclopropanesulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and internal standards. We support cGMP requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.