Description

3-p-Tolyl-[1,2,4]Triazolo[4,3-A]Pyridine-8-Carboxylic Acid is a high-value heterocyclic carboxylic acid building block, primarily utilized in advanced pharmaceutical research and development. This compound matters as a critical synthetic intermediate for constructing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is essential for medicinal chemists and process development scientists working in pharmaceutical, agrochemical, and fine chemical synthesis who require reliable, high-purity intermediates to accelerate their R&D pipelines.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its fused triazolopyridine core.
• Material Science Precursor: Serves as a functionalized ligand or monomer for creating advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Employed to create tool compounds and probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.
• Academic & Institutional Research: Used in university and government labs for fundamental research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	3-p-Tolyl-[1,2,4]Triazolo[4,3-A]Pyridine-8-Carboxylic Acid
CAS No.	1082193-74-5
Molecular Formula	C15H11N3O2
Molecular Weight	265.27 g/mol
Synonyms	3-(4-Methylphenyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylic acid; 8-Carboxy-3-p-tolyl-[1,2,4]triazolo[4,3-a]pyridine; 3-(p-Tolyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylic acid; 1082193-74-5; 3-(4-Methylphenyl)-1,2,4-triazolo[4,3-a]pyridine-8-carboxylic acid; Triazolopyridine-8-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 3-p-Tolyl-[1,2,4]Triazolo[4,3-A]Pyridine-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client requirements or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.