Description

3-(tert-Butyldimethylsilyloxy)-2-Hydroxy-2-o-Tosyl-Propanenitrile is a high-value, multi-functional synthetic intermediate featuring a protected hydroxyl group and a versatile nitrile moiety. This compound is critical for enabling complex organic syntheses, particularly in the construction of chiral molecules and advanced pharmaceutical scaffolds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral drugs, protease inhibitors, and other complex bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, ligands, and catalysts used in asymmetric synthesis.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, particularly in reactions involving silicon protecting groups and cyanohydrin chemistry.
• Material Science Research: Potential intermediate in the development of advanced polymers and functional materials.

Basic Information

Product Name	3-(tert-Butyldimethylsilyloxy)-2-Hydroxy-2-o-Tosyl-Propanenitrile
CAS No.	1079950-23-4
Molecular Formula	C16H25NO4SSi
Molecular Weight	355.53 g/mol
Synonyms	2-Hydroxy-2-[(4-methylphenyl)sulfonyl]-3-[(2-methyl-2-propanyl)dimethylsilyl]oxy]propanenitrile; 2-Hydroxy-3-((tert-butyldimethylsilyl)oxy)-2-(p-tolylsulfonyl)propanenitrile; α-Hydroxy-α-tosylacetonitrile TBDMS ether; TBDMS-protected Tosyl Cyanohydrin; (RS)-2-Hydroxy-3-[(tert-butyldimethylsilyl)oxy]-2-(4-tolylsulfonyl)propanenitrile
EINECS	Contact for details

Quality Control

Our production of 3-(tert-Butyldimethylsilyloxy)-2-Hydroxy-2-o-Tosyl-Propanenitrile adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.