Description

3-[(1,1-Dimethylethyl)Dimethylsilyloxy]-5-(1-Methylamino)-5-Oxopentanoic Acid Methyl Ester is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex peptide mimetics and other biologically active molecules, offering precise control over stereochemistry and functional group manipulation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of peptide-based drug candidates and protease inhibitors.
• Peptidomimetic Research: Used to introduce protected amino acid motifs into non-peptide scaffolds for drug discovery.
• Chemical Biology Probes: Employed in the construction of labeled or modified peptides for studying biological pathways.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing bespoke organic compounds.
• Academic Research: Utilized in university laboratories for methodological development in synthetic organic chemistry.

Basic Information

Product Name	3-[(1,1-Dimethylethyl)Dimethylsilyloxy]-5-(1-Methylamino)-5-Oxopentanoic Acid Methyl Ester
CAS No.	1076199-67-1
Molecular Formula	C14H29NO4Si
Molecular Weight	303.48 g/mol
Synonyms	Methyl 3-[(tert-butyldimethylsilyl)oxy]-5-(methylamino)-5-oxopentanoate; 5-Oxo-5-(methylamino)pentanoic Acid 3-[(1,1-Dimethylethyl)dimethylsilyl] Ester, Methyl Ester; TBDMS-protected Methyl Glutamate Derivative; N-Methyl-3-[(tert-butyldimethylsilyl)oxy]glutamic Acid Dimethyl Ester; tert-Butyldimethylsilyl Glutamate Methyl Ester Derivative; CAS 1076199-67-1
EINECS	Contact for details

Quality Control

Our production of 3-[(1,1-Dimethylethyl)Dimethylsilyloxy]-5-(1-Methylamino)-5-Oxopentanoic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and MS are provided with each shipment. We support compliance with cGMP guidelines for advanced intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.