Description

n-(3-tert-Butyldimethylsilyloxy-2,2-Dimethylbutyryloxy)Succinimide is a specialized, high-purity chemical intermediate designed for advanced synthetic applications. Its core value lies in its role as a versatile building block, enabling the controlled introduction of protected functional groups into complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities. Its design facilitates precise molecular construction where stability and selectivity are paramount.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide & Protein Chemistry: Used in the preparation of protected amino acid derivatives and for modifying biomolecules.
• Organic Synthesis Reagent: Functions as an acylating or coupling agent in the formation of amide bonds under mild conditions.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) moiety serves as a robust protecting group for alcohols during complex synthetic sequences.
• Research & Development: Critical for medicinal chemistry and process chemistry research in developing new therapeutic candidates.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring high-purity intermediates.

Basic Information

Product Name	n-(3-tert-Butyldimethylsilyloxy-2,2-Dimethylbutyryloxy)Succinimide
CAS No.	1076199-64-8
Molecular Formula	C16H29NO5Si
Molecular Weight	343.50 g/mol
Synonyms	N-[(3-{[tert-Butyl(dimethyl)silyl]oxy}-2,2-dimethylbutanoyl)oxy]succinimide; 2,5-Pyrrolidinedione, 1-[(3-{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethyl-1-oxobutyl)oxy]-; TBDMS-protected hydroxy acid succinimide ester; 3-(tert-Butyldimethylsilyloxy)-2,2-dimethylbutyric acid N-hydroxysuccinimide ester; NHS ester of TBDMS-protected DMBA; N-Succinimidyl 3-(tert-butyldimethylsilyloxy)-2,2-dimethylbutyrate
EINECS	Contact for details

Quality Control

Our n-(3-tert-Butyldimethylsilyloxy-2,2-Dimethylbutyryloxy)Succinimide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and cGMP manufacturing environments. All products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.