Description

3-(4-Methylquinolinylamino)-5-(3-Pyrimidinyl)Pyridine is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1076198-59-8. This heterocyclic compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing targeted kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for oncology and inflammatory disease targets.
• Kinase Inhibitor Research: Serves as a core scaffold or precursor in the development of potent and selective kinase inhibitors due to its quinoline and pyrimidine motifs.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Biochemical Assay Development: Employed as a reference standard or probe molecule in high-throughput screening (HTS) and biochemical assay development.
• Academic & Contract Research: Essential for academic research institutions and CROs (Contract Research Organizations) exploring new chemical entities and biological pathways.
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects, from milligram-scale research to kilogram-scale process development and cGMP manufacturing.

Basic Information

Product Name	3-(4-Methylquinolinylamino)-5-(3-Pyrimidinyl)Pyridine
CAS No.	1076198-59-8
Molecular Formula	C19H15N5
Molecular Weight	313.36 g/mol
Synonyms	3-[(4-Methylquinolin-2-yl)amino]-5-(pyrimidin-5-yl)pyridine; 5-(Pyrimidin-5-yl)-N-(4-methylquinolin-2-yl)pyridin-3-amine; 3-(4-Methyl-2-quinolinylamino)-5-(5-pyrimidinyl)pyridine; 1076198-59-8; UNII-9J6I9V16QO; 9J6I9V16QO; BDBM50388825; AKOS025310923; ZINC000004098756; A1B.001.003
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Methylquinolinylamino)-5-(3-Pyrimidinyl)Pyridine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing results from HPLC, NMR, and MS. Our quality commitment supports compliance with ISO standards and meets the rigorous demands of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.