Description

tert-Butyl n-[(tert-Butoxy)Carbonyl]-n-(3-Ethynylpyridin-2-Yl)Carbamate (Wx686205) is a specialized, high-purity chemical building block featuring a unique pyridine core functionalized with both a Boc-protected amine and an ethynyl group. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its versatile reactive handles (Boc group and alkyne).
• Click Chemistry: The terminal alkyne moiety enables efficient conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation or polymer synthesis.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Used to create labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for the contract manufacturing of bespoke, high-value fine chemicals.

Basic Information

Product Name	tert-Butyl n-[(tert-Butoxy)Carbonyl]-n-(3-Ethynylpyridin-2-Yl)Carbamate (Wx686205)
CAS No.	1075734-32-5
Molecular Formula	C17H22N2O4
Molecular Weight	318.37 g/mol
Synonyms	tert-Butyl N-(tert-butoxycarbonyl)-N-(3-ethynylpyridin-2-yl)carbamate; 2-Pyridinecarboxamide, N-(1,1-dimethylethoxy)carbonyl-N-(3-ethynyl-2-pyridinyl)-, 1,1-dimethylethyl ester; WX-686205; WX686205; BOC-Protected 3-Ethynyl-2-aminopyridine Derivative; Di-Boc 3-Ethynyl-2-aminopyridine; (3-Ethynylpyridin-2-yl)carbamic acid tert-butyl ester, N-Boc protected.
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[(tert-Butoxy)Carbonyl]-n-(3-Ethynylpyridin-2-Yl)Carbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.