Description

2-(4-Boc-Piperazin-1-Yl)-3-Methylpyridine-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and building block. This compound is critical for facilitating efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the rapid synthesis of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing piperazine and pyridine motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds for constructing biaryl and heterobiaryl structures in medicinal chemistry.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a scalable intermediate for route scouting and pilot-scale synthesis of target molecules.
• Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.
• Agrochemical Research: Potential application as an intermediate in the development of novel crop protection agents.

Basic Information

Product Name	2-(4-Boc-Piperazin-1-Yl)-3-Methylpyridine-5-Boronic Acid Pinacol Ester
CAS No.	1073354-54-7
Molecular Formula	C21H32BN3O4
Molecular Weight	401.31 g/mol
Synonyms	2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-3-methylpyridine-5-boronic acid pinacol ester; 3-Methyl-2-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-5-pyridineboronic acid, pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-3-methylpyridine; 2-(N-Boc-piperazinyl)-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; BOC-Piperazine-Pyridine-Boronate Ester
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazin-1-Yl)-3-Methylpyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.