Description

6-(4-(Ethoxycarbonyl)Piperazin-1-Yl)Pyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a versatile organoboron building block. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a critical step in constructing complex molecules for drug discovery and development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality synthetic reagents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing pyridine and piperazine motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron reagent for forming carbon-carbon bonds between aromatic rings, enabling the construction of complex biaryl structures.
• Drug Discovery & Medicinal Chemistry: Used in library synthesis and lead optimization for creating novel compounds targeting various diseases.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science: Potential use in the synthesis of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Contract Research & Manufacturing (CRO/CMO): A reliable, specification-controlled raw material for custom synthesis and scale-up projects.

Basic Information

Product Name	6-(4-(Ethoxycarbonyl)Piperazin-1-Yl)Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1073354-26-3
Molecular Formula	C19H28BN3O4
Molecular Weight	373.25 g/mol
Synonyms	6-[4-(Ethoxycarbonyl)-1-piperazinyl]-3-pyridineboronic acid pinacol ester; 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-4-(ethoxycarbonyl)piperazine; 6-(4-(Ethoxycarbonyl)piperazin-1-yl)pyridine-3-boronic acid pinacol ester; 3-Borono-6-(4-ethoxycarbonyl-1-piperazinyl)pyridine pinacol ester; Pinacol 6-(4-(ethoxycarbonyl)piperazin-1-yl)pyridin-3-ylboronate; CAS 1073354-26-3; Boronic acid, B-[6-[4-[(ethoxycarbonyl)amino]-1-piperazinyl]-3-pyridinyl]-, pinacol ester (related isomer)
EINECS	Contact for details

Quality Control

Our 6-(4-(Ethoxycarbonyl)Piperazin-1-Yl)Pyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.