Description

2-[4-(4-Chlorophenylsulfonyl)Piperazin-1-Yl]Pyridine-5-Boronic Acid, Pinacol Ester is a sophisticated boronic ester derivative, a key building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperazine-sulfonyl scaffold that offers versatile pharmacophore modification. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the discovery and development of novel small molecule therapeutics and active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: The pinacol-protected boronic ester group serves as a stable, air-tolerant reagent for forming carbon-carbon bonds, enabling the construction of complex biaryl structures common in drug molecules.
• Medicinal Chemistry & Drug Discovery: Used extensively in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides, leveraging its unique heterocyclic core for bioactivity.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and metal-organic frameworks (MOFs) due to its conjugated system and metal-coordinating potential.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from milligram to kilogram.

Basic Information

Product Name	2-[4-(4-Chlorophenylsulfonyl)Piperazin-1-Yl]Pyridine-5-Boronic Acid, Pinacol Ester
CAS No.	1073354-20-7
Molecular Formula	C21H25BClN3O4S
Molecular Weight	461.77 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]pyridine; 2-(4-(4-Chlorophenylsulfonyl)piperazin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pyridine, 2-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-[4-(4-Chloro-benzenesulfonyl)-piperazin-1-yl]-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine; Boronic acid, B-[2-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-5-pyridinyl]-, pinacol ester; CAS 1073354-20-7
EINECS	Contact for details

Quality Control

Our production of 2-[4-(4-Chlorophenylsulfonyl)Piperazin-1-Yl]Pyridine-5-Boronic Acid, Pinacol Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.