Description

tert-Butyl 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is a high-purity, protected boronic ester derivative crucial for modern synthetic chemistry. This compound serves as a key advanced pharmaceutical intermediate (API intermediate) for constructing complex molecular architectures via cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical building block for forming carbon-carbon bonds in the synthesis of complex heterocyclic compounds.
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those containing the privileged 7-azaindole (pyrrolo[2,3-b]pyridine) scaffold.
• Agrochemical Synthesis: Serves as a precursor in creating novel pesticides and herbicides with enhanced efficacy.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated system.
• Chemical Biology Probes: Useful for creating tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry & Scale-up: Provides a stable, protected boronate form for reliable and scalable manufacturing processes.

Basic Information

Product Name	tert-Butyl 5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate
CAS No.	1073338-93-8
Molecular Formula	C18H24BFN2O4
Molecular Weight	362.21 g/mol
Synonyms	1-Boc-5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 5-Fluoro-1-Boc-3-(pinacolatoB)-7-azaindole; 1-Boc-5-fluoro-3-pinacolboronate-7-azaindole; 1073338-93-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material suitable for advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.