Description

2-Chloro-6-Trifluoromethyl-Nicotinic Acid Methyl Ester is a high-value, multi-functional chemical intermediate characterized by its halogenated pyridine core. This compound matters for its role as a critical building block in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique trifluoromethyl and chloro substituents impart desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, insecticides, and fungicides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Pharmaceutical Building Block: Used in medicinal chemistry for the research and development of active pharmaceutical ingredients (APIs), particularly in candidates targeting neurological and metabolic diseases.
• Ligand and Catalyst Synthesis: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of advanced organic electronic materials and liquid crystals due to its electron-withdrawing groups.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for client projects.

Basic Information

Product Name	2-Chloro-6-Trifluoromethyl-Nicotinic Acid Methyl Ester
CAS No.	1073129-57-3
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	Methyl 2-chloro-6-(trifluoromethyl)nicotinate; 2-Chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid methyl ester; Methyl 2-chloro-6-(trifluoromethyl)-3-pyridinecarboxylate; 3-Pyridinecarboxylic acid, 2-chloro-6-(trifluoromethyl)-, methyl ester; 2-Chloro-6-trifluoromethylnicotinic acid methyl ester; 2-Chloro-6-trifluoromethyl-3-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Trifluoromethyl-Nicotinic Acid Methyl Ester is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment. Our quality commitment supports cGMP and ISO 9001 aligned processes for reliable scale-up from research to commercial quantities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.