Description

2-Bromo-5-Methoxypyridine-4-Boronic Acid CAS NO 1072952-48-7 is a high-value boronic acid derivative and a versatile building block in modern synthetic chemistry. Its core value proposition lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable, high-purity intermediate for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, leveraging its pyridine core for bioactive molecule design.
• Material Science Research: Serves as a precursor for creating functionalized organic ligands and monomers used in advanced polymers and electronic materials.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura coupling to form biaryl and heterobiaryl structures, a fundamental transformation in medicinal chemistry.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	2-Bromo-5-Methoxypyridine-4-Boronic Acid
CAS No.	1072952-48-7
Molecular Formula	C6H7BBrNO3
Molecular Weight	231.84 g/mol
Synonyms	(2-Bromo-5-methoxypyridin-4-yl)boronic acid; 4-Borono-2-bromo-5-methoxypyridine; 2-Bromo-5-methoxy-4-pyridineboronic acid; 5-Methoxy-2-bromopyridine-4-boronic acid; Boronic acid, B-(2-bromo-5-methoxy-4-pyridinyl)-; 1072952-48-7; 2-Bromo-5-methoxypyridine-4-boronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Methoxypyridine-4-Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.