Description

2-Chloro-3-Fluoro-5-Picoline-4-Boronic Acid is a high-purity, multi-functional heterocyclic boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its role as a versatile building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. This compound is critically needed by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in next-generation herbicides, fungicides, and insecticides.
• Ligand & Catalyst Development: Serves as a building block for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its functionalized pyridine core.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs and fine chemical suppliers serving the global life sciences market.

Basic Information

Product Name	2-Chloro-3-Fluoro-5-Picoline-4-Boronic Acid
CAS No.	1072952-39-6
Molecular Formula	C7H6BClFNO2
Molecular Weight	188.39 g/mol
Synonyms	2-Chloro-3-fluoro-5-methylpyridine-4-boronic acid; (2-Chloro-3-fluoro-5-methylpyridin-4-yl)boronic acid; 4-Borono-2-chloro-3-fluoro-5-picoline; 2-Chloro-3-fluoro-5-methyl-4-pyridineboronic acid; 1072952-39-6; 2-Chloro-3-fluoro-5-methyl-4-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoro-5-Picoline-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.