Description

6-((Tetrahydrofuran-3-Yl)Oxy)Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique nicotinic acid core modified with a tetrahydrofuran-3-yloxy substituent. This structural motif is critical for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular interactions. It is essential for research and development chemists and process scale-up teams in the global pharmaceutical and biotechnology sectors. The compound, identified by CAS No. 1072855-68-5, is supplied under stringent quality controls to ensure batch-to-batch consistency for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or metabolic diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for potential APIs under Good Manufacturing Practice (GMP) guidelines.
• Bioconjugation & Prodrug Development: The reactive carboxylic acid group enables its use in creating prodrugs or bioconjugates to enhance drug delivery and targeting.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for investigating biological pathways and enzyme functions.

Basic Information

Product Name	6-((Tetrahydrofuran-3-Yl)Oxy)Nicotinic Acid
CAS No.	1072855-68-5
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	6-[(Oxolan-3-yl)oxy]pyridine-3-carboxylic acid; 6-(Tetrahydrofuran-3-yloxy)nicotinic acid; 3-Pyridinecarboxylic acid, 6-[(tetrahydro-3-furanyl)oxy]-; Nicotinic acid, 6-((tetrahydro-3-furanyl)oxy)-; 6-(THF-3-yloxy)nicotinic acid; 6-(3-Tetrahydrofuranyloxy)nicotinic Acid
EINECS	Contact for details

Quality Control

Our 6-((Tetrahydrofuran-3-Yl)Oxy)Nicotinic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and conformity to client specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development and commercial projects with custom purity grades and can provide materials suitable for research use through to cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.