Description

6-(2,2-Difluoroethoxy)Nicotinic Acid is a high-value fluorinated nicotinic acid derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the unique reactivity imparted by the difluoroethoxy moiety, enabling precise molecular modifications. This compound is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in the development of fluorinated drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for advanced materials, such as liquid crystals or organic semiconductors.
• Chemical Biology Probes: Useful for designing fluorinated molecular probes to study enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	6-(2,2-Difluoroethoxy)Nicotinic Acid
CAS No.	1072855-41-4
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	6-(2,2-Difluoroethoxy)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-(2,2-difluoroethoxy)-; Nicotinic acid, 6-(2,2-difluoroethoxy)-; 2,2-Difluoroethoxy Nicotinic Acid; 6-(Difluoroethoxy)nicotinic Acid; 5-Carboxy-2-(2,2-difluoroethoxy)pyridine
EINECS	Contact for details

Quality Control

Our 6-(2,2-Difluoroethoxy)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.