Description

Fmoc-Leu-Bt CAS NO 1072840-99-3 is a high-purity, protected amino acid derivative specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the efficient and controlled assembly of complex peptides and proteins in research and pharmaceutical development. It is essential for scientists and manufacturers in the fields of medicinal chemistry, bioconjugation, and proteomics who require reliable, high-quality reagents for advanced peptide production.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester (Bt ester), it facilitates the rapid and efficient coupling of Fmoc-Leucine during automated or manual peptide chain elongation.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of novel therapeutic peptides targeting various diseases, where leucine incorporation is crucial for structure and activity.
• Bioconjugation: Serves as a key reagent for introducing leucine residues into labeled peptides, proteins, or other biomolecules for diagnostic or targeting applications.
• Combinatorial Library Synthesis: Enables the high-throughput creation of diverse peptide libraries for screening in pharmaceutical and biochemical research.
• Proteomics Research: Employed in the synthesis of peptide standards, substrates for enzyme studies, and probes for protein-protein interaction analysis.
• Custom Peptide Service Providers: A fundamental raw material for CROs and manufacturers offering bespoke peptide synthesis services to academic and industrial clients.

Basic Information

Product Name	Fmoc-Leu-Bt
CAS No.	1072840-99-3
Molecular Formula	C26H28N2O5
Molecular Weight	448.52 g/mol
Synonyms	Fmoc-L-leucine benzotriazolyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-leucine benzotriazole ester; Fmoc-Leu-OBt; 1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-leucyl)-1H-benzotriazole; Fmoc-Leucine Bt ester; Fmoc-Leu-OBzt; N-α-Fmoc-L-leucine benzotriazol-1-yl ester; Fmoc-Leu-Benzotriazolide
EINECS	Contact for details

Quality Control

Our Fmoc-Leu-Bt is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.