Description

1-Fmoc-4-(Hydroxymethyl)Piperidine is a high-purity, protected piperidine derivative that serves as a critical building block in modern organic synthesis. This compound is essential for the efficient construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of peptide mimetics and other bioactive compounds targeting neurological and oncological pathways.
• Peptidomimetic Scaffold Development: Used to introduce the piperidine moiety with orthogonal protecting groups, enabling the creation of libraries for drug discovery and structure-activity relationship (SAR) studies.
• Linker Chemistry: Employed in the synthesis of antibody-drug conjugates (ADCs) and prodrugs, where the hydroxymethyl group provides a handle for conjugation.
• Chemical Biology Probes: Serves as a building block for creating fluorescent or affinity-labeled probes to study enzyme function and protein-protein interactions.
• Agrochemical Research: Utilized in the development of novel herbicides and fungicides that incorporate heterocyclic amine structures.

Basic Information

Product Name	1-Fmoc-4-(Hydroxymethyl)Piperidine
CAS No.	1072502-03-4
Molecular Formula	C22H25NO3
Molecular Weight	351.44 g/mol
Synonyms	4-(Hydroxymethyl)-1-(9H-fluoren-9-ylmethoxycarbonyl)piperidine; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(hydroxymethyl)piperidine; 1-Fmoc-4-piperidinemethanol; 4-(Hydroxymethyl)-1-Fmoc-piperidine; N-Fmoc-4-piperidinemethanol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(hydroxymethyl)piperidine; Fmoc-4-(hydroxymethyl)piperidine; 1-[(9-Fluorenylmethyloxycarbonyl)]-4-(hydroxymethyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-Fmoc-4-(Hydroxymethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.