Description

(3Ar,4R,7Ar)-3A,7A-Dihydro-2-Methyl-4-[(1R,2R)-1,2,3-Trihydroxypropyl]-4H-Pyrano[3,4-D]Oxazole-6-Carboxylic Acid Methyl Ester is a high-purity, chiral organic compound featuring a complex fused pyrano-oxazole structure. This molecule is of significant interest as a sophisticated synthetic intermediate or a potential pharmacophore in advanced pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists working in the fields of medicinal chemistry and fine chemical synthesis. The compound's defined stereochemistry and functional groups make it a valuable building block for creating novel active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex target molecules under current Good Manufacturing Practice (cGMP) guidelines.
• Asymmetric Synthesis: Utilized as a substrate or template in catalytic asymmetric transformations to construct other stereochemically complex molecules.
• Reference Standard: Provides a high-purity analytical standard for method development and quality control in API manufacturing.
• Bioconjugation Chemistry: The carboxylic acid methyl ester and hydroxyl groups offer handles for further chemical modification and linker attachment in prodrug or antibody-drug conjugate (ADC) development.

Basic Information

Product Name	(3Ar,4R,7Ar)-3A,7A-Dihydro-2-Methyl-4-[(1R,2R)-1,2,3-Trihydroxypropyl]-4H-Pyrano[3,4-D]Oxazole-6-Carboxylic Acid Methyl Ester
CAS No.	1072449-83-2
Molecular Formula	C₁₄H₁₉NO₇
Molecular Weight	313.30 g/mol
Synonyms	Methyl (3aR,4R,7aR)-2-methyl-4-[(1R,2R)-1,2,3-trihydroxypropyl]-3a,4,7,7a-tetrahydro-1H-pyrano[3,4-d]oxazole-6-carboxylate; (3aR,4R,7aR)-2-Methyl-4-[(1R,2R)-1,2,3-trihydroxypropyl]-3a,4,7,7a-tetrahydro-1H-pyrano[3,4-d]oxazole-6-carboxylic Acid Methyl Ester; Pyrano[3,4-d]oxazole-6-carboxylic Acid Derivative; Chiral Pyrano-Oxazole Ester; CAS 1072449-83-2
EINECS	Contact for details

Quality Control

Our production of (3Ar,4R,7Ar)-3A,7A-Dihydro-2-Methyl-4-[(1R,2R)-1,2,3-Trihydroxypropyl]-4H-Pyrano[3,4-D]Oxazole-6-Carboxylic Acid Methyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere at 2-8°C to maintain optimal stability, as the compound may be hygroscopic and sensitive to oxidation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.