Description

Imidazo[1,2-A]Pyridine-6-Thiol, 2-(Trifluoromethyl)- is a high-value, heterocyclic building block characterized by its fused imidazole-pyridine core, thiol functionality, and a strategically positioned trifluoromethyl group. This compound is essential for medicinal chemistry and advanced materials research, where its unique structure enables the synthesis of novel molecules with tailored properties. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty organic materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Biology Probe Development: Utilized to create tool compounds and probes for studying enzyme mechanisms and protein interactions due to its reactive thiol group.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	Imidazo[1,2-A]Pyridine-6-Thiol, 2-(Trifluoromethyl)-
CAS No.	1072433-61-4
Molecular Formula	C8H5F3N2S
Molecular Weight	218.20 g/mol
Synonyms	2-(Trifluoromethyl)imidazo[1,2-a]pyridine-6-thiol; 2-(Trifluoromethyl)-6-mercaptoimidazo[1,2-a]pyridine; 6-Mercapto-2-(trifluoromethyl)imidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine-6-thiol, 2-(trifluoromethyl)-; 1072433-61-4; 2-Trifluoromethyl-imidazo[1,2-a]pyridine-6-thiol
EINECS	Contact for details

Quality Control

Our Imidazo[1,2-A]Pyridine-6-Thiol, 2-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.