Description

5-Bromo-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and trifluoromethylated pyridone structure. This compound is critical for medicinal chemistry research and development, offering a versatile building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to incorporate its specific bromine and trifluoromethyl motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Used in the research and synthesis of new-generation pesticides and herbicides, leveraging the biological activity of the pyridone core.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) producing specialized compounds for client projects.
• Academic Research: Used in university and institutional labs for fundamental studies in heterocyclic chemistry and fluorinated compound synthesis.

Basic Information

Product Name	5-Bromo-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide
CAS No.	1072022-41-3
Molecular Formula	C7H4BrF3N2O2
Molecular Weight	285.02 g/mol
Synonyms	5-Bromo-6-(trifluoromethyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; 5-Bromo-2-oxo-6-(trifluoromethyl)-1H-pyridine-3-carboxamide; 3-Carbamoyl-5-bromo-6-(trifluoromethyl)pyridin-2(1H)-one; 5-Bromo-6-trifluoromethyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid amide; CAS 1072022-41-3
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids/bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.