Description

(1S)Cyclopropyl[6-(Trifluoromethyl)(3-Pyridyl)]Methylamine is a high-value, chiral amine building block featuring a cyclopropyl and a trifluoromethylpyridyl moiety. This compound is critical for medicinal chemistry research and development, offering unique steric and electronic properties to modulate the pharmacokinetics and potency of drug candidates. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel small-molecule therapeutics, particularly in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the cyclopropyl and trifluoromethyl groups.
• Protease Inhibitor Synthesis: Serves as a building block for inhibitors targeting various protease enzymes.
• Kinase Inhibitor Development: Incorporated into potential kinase inhibitor candidates for oncology applications.
• Agrochemical Research: Employed in the discovery of advanced crop protection agents with improved efficacy.
• Ligand Synthesis: Used for preparing specialized ligands in catalysis and chemical biology.

Basic Information

Product Name	(1S)Cyclopropyl[6-(Trifluoromethyl)(3-Pyridyl)]Methylamine
CAS No.	1071655-12-3
Molecular Formula	C10H11F3N2
Molecular Weight	216.20 g/mol
Synonyms	(1S)-1-Cyclopropyl-1-[6-(trifluoromethyl)pyridin-3-yl]methanamine; (S)-1-Cyclopropyl-1-(6-(trifluoromethyl)pyridin-3-yl)methanamine; (S)-[6-(Trifluoromethyl)pyridin-3-yl](cyclopropyl)methylamine; (S)-Cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methylamine; (S)-α-Cyclopropyl-6-(trifluoromethyl)-3-pyridinemethanamine; 1071655-12-3; (1S)-Cyclopropyl[6-(trifluoromethyl)-3-pyridinyl]methylamine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purity levels of ≥97% (by HPLC) and ≥99% ee (by chiral HPLC), meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.