Description

trans-tert-Butyl3-Fluoro-4-(Methylsulfonyloxy)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with key fluorinated and mesylate leaving group functionalities. This compound is specifically engineered for use in sophisticated multi-step synthesis, enabling the efficient construction of complex bioactive molecules. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Agrochemical Research: Serves as a key precursor in the development of new-generation pesticides and herbicides, leveraging its unique fluorinated structure.
• Chemical Biology Probes: Used in the creation of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	trans-tert-Butyl3-Fluoro-4-(Methylsulfonyloxy)Piperidine-1-Carboxylate
CAS No.	1070896-84-2
Molecular Formula	C12H22FNO5S
Molecular Weight	311.37 g/mol
Synonyms	1-Boc-3-fluoro-4-(methylsulfonyloxy)piperidine (trans); trans-1-(tert-Butoxycarbonyl)-3-fluoro-4-(methylsulfonyloxy)piperidine; trans-N-Boc-3-fluoro-4-mesyloxypiperidine; trans-tert-Butyl 3-fluoro-4-[(methylsulfonyl)oxy]-1-piperidinecarboxylate; 1-Piperidinecarboxylic acid, 3-fluoro-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (3R,4S)-rel-; 1070896-84-2; Boc-3-fluoro-4-OMs-piperidine (trans)
EINECS	Contact for details

Quality Control

Our trans-tert-Butyl3-Fluoro-4-(Methylsulfonyloxy)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.