Description

5-Bromo-2-(trifluoromethyl)isonicotinonitrile is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both bromo and trifluoromethyl substituents on the pyridine ring, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used to construct advanced pyridine-based herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to create diverse biaryl structures.
• Fluorine Chemistry: The trifluoromethyl group is a valuable, metabolically stable bioisostere used to modulate lipophilicity and bioavailability in lead optimization.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	5-Bromo-2-(trifluoromethyl)isonicotinonitrile
CAS No.	1070892-04-4
Molecular Formula	C7H2BrF3N2
Molecular Weight	250.00 g/mol
Synonyms	5-Bromo-2-(trifluoromethyl)pyridine-4-carbonitrile; 4-Cyano-5-bromo-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-5-bromo-4-pyridinecarbonitrile; 5-Bromo-2-trifluoromethylisonicotinonitrile; 1070892-04-4; 5-Bromo-2-(trifluoromethyl)-4-cyanopyridine; Isonicotinonitrile, 5-bromo-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethyl)isonicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable performance in your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong alkali and fluoride ions; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.