Description

2-Bromo-4-Chloro-3-Iodo-Pyridine is a highly functionalized halogenated pyridine derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique substitution pattern offers distinct reactivity for selective cross-coupling and nucleophilic substitution reactions, enabling the construction of complex molecular architectures. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides with specific modes of action.
• Material Science: Used in the creation of functionalized ligands for catalysis and as a monomer for specialty polymers.
• Chemical Research: Versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: Serves as a substrate for Suzuki, Stille, and Negishi couplings due to the presence of bromo and iodo groups with different reactivities.
• Nucleophilic Aromatic Substitution: The chloro and fluoro-like activating groups make it suitable for displacement reactions with various nucleophiles.

Basic Information

Product Name	2-Bromo-4-Chloro-3-Iodo-Pyridine
CAS No.	1070870-41-5
Molecular Formula	C5H2BrClIN
Molecular Weight	318.34 g/mol
Synonyms	3-Iodo-2-bromo-4-chloropyridine; 4-Chloro-2-bromo-3-iodopyridine; Pyridine, 2-bromo-4-chloro-3-iodo-; 2-Bromo-4-chloro-3-iodopyridine; 1070870-41-5; BCP-I; 4-Chloro-3-iodo-2-bromopyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Chloro-3-Iodo-Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤3.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.