Description

Succinimidyl (2R)-6-(Tetrahydro-2H-Pyran-2-Yloxy)-2,5,7,8-Tetramethylchroman-2-Carboxylate is a specialized active ester derivative of a tocopherol analog, designed for efficient bioconjugation and labeling applications. This compound is a critical reagent for researchers and manufacturers requiring the stable and site-specific attachment of the antioxidant chroman moiety to biomolecules like proteins, peptides, or oligonucleotides. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for developing novel drug conjugates, diagnostic probes, and advanced biomaterials.

Application

• Bioconjugation Reagent: Used for the covalent attachment of the tocopherol-derived chroman structure to amino groups on proteins, antibodies, or peptides to impart antioxidant properties or as a hydrophobic tag.
• Proteomics & Biomarker Research: Serves as a building block for synthesizing activity-based probes or affinity tags to study protein function, localization, and interactions.
• Drug Delivery Systems: Employed in the synthesis of prodrugs or antibody-drug conjugates (ADCs) where the chroman unit acts as a lipophilic carrier or a functional payload.
• Polymer & Material Science: Acts as a functional monomer or cross-linker for creating novel polymers with inherent antioxidant or UV-protective characteristics.
• Diagnostic Agent Synthesis: Utilized in the preparation of contrast agents or fluorescent probes for imaging applications, leveraging the succinimidyl ester for stable amide bond formation.
• Chemical Biology Tool Development: A key intermediate for creating chemical probes to investigate oxidative stress pathways and cellular protection mechanisms.

Basic Information

Product Name	Succinimidyl (2R)-6-(Tetrahydro-2H-Pyran-2-Yloxy)-2,5,7,8-Tetramethylchroman-2-Carboxylate
CAS No.	1069137-73-0
Molecular Formula	C24H33NO7
Molecular Weight	447.52 g/mol
Synonyms	(2R)-6-[(Tetrahydro-2H-pyran-2-yl)oxy]-2,5,7,8-tetramethyl-2-chromancarboxylic acid 2,5-dioxo-1-pyrrolidinyl ester; (R)-6-(Tetrahydro-2H-pyran-2-yloxy)-2,5,7,8-tetramethylchroman-2-carboxylic acid N-hydroxysuccinimide ester; THP-protected Trolox NHS ester; Trolox-THP NHS ester; Vitamin E analog NHS ester (THP-protected); NSC 1069137-73-0; Succinimidyl (R)-6-(THP-oxy)-2,5,7,8-tetramethylchroman-2-carboxylate
EINECS	Contact for details

Quality Control

Our Succinimidyl (2R)-6-(Tetrahydro-2H-Pyran-2-Yloxy)-2,5,7,8-Tetramethylchroman-2-Carboxylate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.