Description

(2-Bromo-5-Fluorophenyl)Acetic Acid Methyl Ester is a high-purity fluorinated and brominated aromatic building block essential for advanced organic synthesis. This compound is valued for its dual halogen functionality, which provides distinct reactive sites for selective cross-coupling and functionalization reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and CNS-active molecule libraries.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides where the halogenated phenylacetic acid scaffold is required.
• Material Science Research: Serves as a precursor for liquid crystals and specialty polymers that incorporate halogenated aromatic units.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Negishi palladium-catalyzed coupling reactions.
• Chemical Derivatization: The methyl ester group can be hydrolyzed to the corresponding acid or trans-esterified, offering a versatile handle for further molecular elaboration.

Basic Information

Product Name	(2-Bromo-5-Fluorophenyl)Acetic Acid Methyl Ester
CAS No.	1069115-12-3
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	Methyl (2-bromo-5-fluorophenyl)acetate; (2-Bromo-5-fluorophenyl)acetic acid methyl ester; Methyl 2-(2-bromo-5-fluorophenyl)acetate; 2-(2-Bromo-5-fluorophenyl)acetic acid methyl ester; 1069115-12-3; Methyl (2-bromo-5-fluorobenzene)acetate; (o-Bromo-p-fluorophenyl)acetic acid methyl ester
EINECS	Contact for details

Quality Control

Our (2-Bromo-5-Fluorophenyl)Acetic Acid Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.