Description

tert-Butyl 5-Bromothiazolo[5,4-B]Pyridin-2-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its fused heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other enzymatic pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: Serves as a starting material for creating labeled compounds and biochemical probes used in diagnostic and mechanistic studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical development pipelines.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 5-Bromothiazolo[5,4-B]Pyridin-2-Ylcarbamate
CAS No.	1067877-78-4
Molecular Formula	C11H10BrN3O2S
Molecular Weight	328.18 g/mol
Synonyms	5-Bromo-2-(((tert-butoxy)carbonyl)amino)thiazolo[5,4-b]pyridine; 2-(((tert-Butoxy)carbonyl)amino)-5-bromothiazolo[5,4-b]pyridine; tert-Butyl N-(5-bromothiazolo[5,4-b]pyridin-2-yl)carbamate; 5-Bromo-thiazolo[5,4-b]pyridine-2-carboxylic acid tert-butylamide (obsolete); TBBC-Thiazolopyridine; BOC-5-Bromo-thiazolopyridine-2-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromothiazolo[5,4-B]Pyridin-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.