Description

1-o-Tolyl-1-Tosylmethyl Isocyanide is a specialized organic building block featuring both an isocyanide and a tosylmethyl group, making it a versatile reagent for multicomponent reactions and heterocyclic synthesis. Its unique structure is critical for constructing complex molecular architectures with high efficiency and selectivity, which is essential for advanced research and development. This compound is primarily sought by pharmaceutical researchers, agrochemical developers, and academic institutions engaged in medicinal chemistry and the discovery of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for libraries of nitrogen-containing heterocycles.
• Agrochemical Research: Used in the development of new pesticides and herbicides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a building block for functional polymers and advanced organic materials with tailored properties.
• Academic & R&D: Employed in multicomponent reactions (MCRs) like the Ugi and Passerini reactions to rapidly generate chemical diversity.
• Medicinal Chemistry: Facilitates the construction of complex scaffolds for probing biological targets and optimizing lead compounds.
• Chemical Biology: Acts as a probe or labeling agent due to the reactive isocyanide functional group.

Basic Information

Product Name	1-o-Tolyl-1-Tosylmethyl Isocyanide
CAS No.	1067658-59-6
Molecular Formula	C16H15NO2S
Molecular Weight	285.36 g/mol
Synonyms	1-(o-Tolyl)-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; 1-(2-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; 1-o-Tolyl-1-(p-tolylsulfonyl)methyl isocyanide; Tosylmethyl isocyanide o-tolyl derivative; TOSMIC o-tolyl derivative; Isocyanide, [((2-methylphenyl)[(4-methylphenyl)sulfonyl]methyl]-; [o-Tolyl(tosyl)methyl] isocyanide
EINECS	Contact for details

Quality Control

Our 1-o-Tolyl-1-Tosylmethyl Isocyanide is manufactured under strict quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.