Description

3(R)-Bromomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-value chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry where the introduction of a functionalized pyrrolidine ring is required. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Protease Inhibitor Synthesis: Used in the construction of pyrrolidine-based scaffolds for inhibitors targeting various proteases.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics: Integral for the synthesis of peptidomimetic compounds where the pyrrolidine structure mimics natural amino acid backbones.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	3(R)-Bromomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1067230-65-2
Molecular Formula	C11H20BrNO2
Molecular Weight	278.19 g/mol
Synonyms	1-Boc-3(R)-bromomethylpyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-(bromomethyl)pyrrolidine; tert-Butyl (3R)-3-(bromomethyl)pyrrolidine-1-carboxylate; (R)-3-Bromomethyl-1-N-Boc-pyrrolidine; 1-N-Boc-3(R)-bromomethylpyrrolidine; (R)-1-Boc-3-(bromomethyl)pyrrolidine; Pyrrolidine-1-carboxylic acid, 3-(bromomethyl)-, 1,1-dimethylethyl ester, (3R)-
EINECS	Contact for details

Quality Control

Our 3(R)-Bromomethyl-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.